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This comes as the American College of Cardiology (ACC) released its five top trends in cardiovascular medicine in 2025, including Anti-Obesity Drugs: Cardiovascular Benefit Beyond Weight Loss. The ACC reports that semaglutide and tirzepatide both demonstrate remarkable cardiovascular benefits that extend beyond weight management. Clinical trials show these medications can reduce the risk of major adverse cardiovascular events by up to 20% in patients with obesity and preexisting cardiovascular conditions

For patients concerned about losing lean muscle mass while using semaglutide or tirzepatide, however, there is some good news: A new study conducted by obesity specialists in New York found that incorporating resistance training, increasing protein intake, and reducing the speed of weight loss can mitigate the risk of GLP-1-associated muscle loss

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